The effect of radiofrequency treatment on insulin resistance in obese post-menopausal women: a randomized controlled trial

Shymaa Mohammed Abdo; Salwa M El-Badry; Wessam Ali Al-kholy; Dalia M Kamel; Hossam H Salem; Mona Ahmed Abdulmohsen

doi:10.15391/prrht.2024-9(3).06

Authors

Shymaa Mohammed Abdo Teaching Fellow EL-Sahel Teaching Hospital, El Sahel Cairo Egypt https://orcid.org/0009-0004-9530-1646
Salwa M El-Badry Department of Physical Therapy for Women's Health, Faculty of Physical Therapy, Cairo University, Egypt https://orcid.org/0000-0003-4805-6532
Wessam Ali Al-kholy Department of Physical Therapy for Women's Health, Faculty of Physical Therapy, Cairo University, Egypt https://orcid.org/0009-0005-1352-2320
Dalia M Kamel Department of Physical Therapy for Women's Health, Faculty of Physical Therapy, Cairo University, Egypt https://orcid.org/0000-0001-8028-6894
Hossam H Salem Department of Gynecology and Obstetrics, Faculty of Medicine, Al Azhar University, Cairo Egypt https://orcid.org/0000-0002-3196-756X
Mona Ahmed Abdulmohsen Teaching Fellow EL-Sahel Teaching Hospital, El Sahel Cairo Egypt https://orcid.org/0009-0008-0016-6146

DOI:

https://doi.org/10.15391/prrht.2024-9(3).06

Keywords:

Menopause, Insulin resistance, Central abdominal obesity, Radiofrequency

Abstract

Abstract.

Purpose: Obese post-menopausal women commonly develop insulin resistance due to a lack of estrogen hormone during menopause. Central abdominal fat and its related cardiovascular diseases are the consequences of insulin resistance. So, it represents a significant medical and socioeconomic issue impacting women’s health and quality of life. To determine the effect of radiofrequency in the treatment of insulin resistance in obese post-menopausal women.

Material and Methods: Fifty-two post-menopausal women who were diagnosed with insulin resistance and abdominal obesity, whose age ranged from 48 to 60 years old, participated in this study. They were recruited from El- Khalil Ebrahem Hospital in Hadaek El Maadi, Cairo. The patients were assigned randomly into two groups equal in number (A & B). Group (A), 26 patients who were treated with radiofrequency (twice/week/4 months), regular diet habits, and medical standard care for insulin resistance, while Group (B), 26 patients treated with regular diet habits and medical standard care for insulin resistance. Outcome measures, HOMA-IR and abdominal fat thickness were assessed prior to and after a four-month treatment duration for both groups.

Results: There was a statistical improvement in HOMA-IR (insulin resistance) and abdominal fat thickness within both groups (A & B) (p < 0.05). Post-treatment comparison revealed better improvement in favor of group A than group B (p < 0.001) respectively.

Conclusion: Adding radiofrequency to selected physical therapy program has improved insulin resistance and decreased abdominal fat in obese post-menopausal women.

References

Abdi Beshir S., Ahmed Elnour A., Soorya A., Parveen Mohamed A., Sir Loon Goh S., Hussain N., Al Haddad AHI., Hussain F., Yousif Khidir I., Abdelnassir Z. (2023). A narrative review of approved and emerging anti-obesity medications. Saudi Pharm J, 31(10), 101757. doi: 10.1016/j.jsps.2023.101757

Belenky I., Margulis A., Elman M., Bar-Yosef U., Paun SD. (2012). Exploring channeling optimized radiofrequency energy: a review of radiofrequency history and applications in esthetic fields. Adv Ther, 29(3), 249-266. doi: 10.1007/s12325-012-0004-1

Ce Cerhan JR., Moore SC., Jacobs EJ., Kitahara CM., Rosenberg PS., Adami HO., Ebbert JO., English DR., Gapstur SM., Giles GG., Horn-Ross PL., Park Y., Patel AV., Robien K., Weiderpass E., Willett WC., Wolk A., Zeleniuch-Jacquotte A., Hartge P., Bernstein L., Berrington de Gonzalez A. (2014). A pooled analysis of waist circumference and mortality in 650,000 adults. Mayo Clin Proc, 89(3), 335-345. doi: 10.1016/j.mayocp.2013.11.011.

Cerhan, J. R., Moore, S. C., Jacobs, E. J., Kitahara, C. M., Rosenberg, P. S., Adami, H. O., Ebbert, J. O., English, D. R., Gapstur, S. M., Giles, G. G., Horn-Ross, P. L., Park, Y., Patel, A. V., Robien, K., Weiderpass, E., Willett, W. C., Wolk, A., Zeleniuch-Jacquotte, A., Hartge, P., Bernstein, L., & Berrington de Gonzalez, A. (2014). A pooled analysis of waist circumference and mortality in 650,000 adults. Mayo Clinic Proceedings, 89(3), 335-345. https://doi.org/10.1016/j.mayocp.2013.11.011

Cornier, M. A. (2022). A review of current guidelines for the treatment of obesity. American Journal of Managed Care, 28(15 Suppl), S288-S296. https://doi.org/10.37765/ajmc.2022.89292

Duncan, D. I., Kim, T. H., & Temaat, R. (2016). A prospective study analyzing the application of radiofrequency energy and high-voltage, ultrashort pulse duration electrical fields on the quantitative reduction of adipose tissue. Journal of Cosmetic and Laser Therapy, 18(5), 257-267. https://doi.org/10.3109/14764172.2016.1157368

Da-Silva, R. M. V., Santos, J. C., de Carvalho, W. L. M., de Vasconcellos, L. S., de Castro, A. B. F., Borges, F. D. S., Carreiro, E. M., & Meyer, P. F. (2022). Effects of Ultracavitation and Radiofrequency on Abdominal Adiposity. J Clin Aesthet Dermatol, 15(1), E66-E71. PMID 35309273; PMCID: PMC8903231.

Davis, S. R., & Baber, R. J. (2022). Treating menopause - MHT and beyond. Nat Rev Endocrinol, 18(8), 490-502. https://doi.org/10.1038/s41574-022-00685-4

Dionysopoulou, S., Charmandari, E., Bargiota, A., Vlahos, N., Mastorakos, G., & Valsamakis, G. (2021). The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders. Nutrients, 13(2), 498. https://doi.org/10.3390/nu13020498

Dube, S., Errazuriz, I., Cobelli, C., Basu, R., & Basu, A. (2013). Assessment of insulin action on carbohydrate metabolism: physiological and non-physiological methods. Diabet Med, 30(6), 664-70. https://doi.org/10.1111/dme.12189

Ferraro, G. A., De Francesco, F., Cataldo, C., Rossano, F., Nicoletti, G., & D’Andrea, F. (2012). Synergistic effects of cryolipolysis and shock waves for noninvasive body contouring. Aesthetic Plast Surg, 36(3), 666-79. https://doi.org/10.1007/s00266-011-9832-7

Gentile, R. D., Kinney, B. M., & Sadick, N. S. (2018). Radiofrequency Technology in Face and Neck Rejuvenation. Facial Plast Surg Clin North Am, 26(2), 123-134. https://doi.org/10.1016/j.fsc.2017.12.003

Kalmykova, Y., & Kalmykov, S. (2023). The effectiveness of the physical therapy program for patients with metabolic syndrome based on the study of the dynamics of the functional state of the autonomic nervous system and hemodynamic parameters. Fizicna Reabilitacia ta Rekreacijno-Ozdorovci Tehnologii, 8(2), 117-127. https://doi.org/10.15391/prrht.2023-8(2).05

Khan, S. J., Kapoor, E., Faubion, S. S., & Kling, J. M. (2023). Vasomotor Symptoms During Menopause: A Practical Guide on Current Treatments and Future Perspectives. Int J Womens Health, 15, 273-287. https://doi.org/10.2147/IJWH.S365808

Kalmykova, Yu.S. (2023). Modern view of the issue of using lifestyle as a means of non-drug therapy of metabolic syndrome. Rehabilitation and Recreation, 16, 37-45. https://doi.org/10.32782/2522-1795.2023.16.5

Kim, T. H., & Chang, M. C. (2021). Comparison of the effectiveness of pulsed radiofrequency of the suprascapular nerve and intra-articular corticosteroid injection for hemiplegic shoulder pain management. J Integr Neurosci, 20(3), 687-693. https://doi.org/10.31083/j.jin2003073

Kuckuck, S., van der Valk, E. S., Scheurink, A. J. W., Lengton, R., Mohseni, M., Visser, J. A., Iyer, A. M., van den Berg, S. A. A., & van Rossum, E. F. C. (2023). Levels of hormones regulating appetite and energy homeostasis in response to a 1.5-Year combined lifestyle intervention for obesity. Front Physiol, 14, 1010858. https://doi.org/10.3389/fphys.2023.1010858

Kalmykova, Y., Kalmykov, S., & Orshatska, N. (2020). Assessment of the reaction of the cardiovascular system to dosed physical activity of patients with metabolic syndrome under the influence of the use of physical therapy. Slobozhanskyi herald of science and sport, 1, 17-24. https://doi:10.15391/snsv.2020-1.003

Li, M., Gong, W., Wang, S., & Li, Z. (2022). Trends in body mass index, overweight and obesity among adults in the USA, the NHANES from 2003 to 2018: a repeat cross-sectional survey. BMJ Open, 12(12), e065425. https://doi.org/10.1136/bmjopen-2022-065425

Marouf, A., & Mortada, H. (2021). Complications of Body Contouring Surgery in Postbariatric Patients: A Systematic Review and Meta-Analysis. Aesthetic Plast Surg, 45(6), 2810-2820. https://doi.org/10.1007/s00266-021-02315-2

Marsh, M. L., Oliveira, M. N., & Vieira-Potter, V. J. (2023). Adipocyte Metabolism and Health after the Menopause: The Role of Exercise. Nutrients, 15(2), 444. https://doi.org/10.3390/nu15020444

Milano, W., Carizzone, F., Foia, M., Marchese, M., Milano, M., Saetta, B., & Capasso, A. (2022). Obesity and Its Multiple Clinical Implications between Inflammatory States and Gut Microbiotic Alterations. Diseases, 11(1), 7. https://doi.org/10.3390/diseases11010007

Neeland, I. J., Ross, R., Després, J. P., Matsuzawa, Y., Yamashita, S., Shai, I., Seidell, J., Magni, P., Santos, R. D., Arsenault, B., Cuevas, A., Hu, F. B., Griffin, B., Zambon, A., Barter, P., Fruchart, J. C., & Eckel, R. H. (2019). Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement. Lancet Diabetes Endocrinol, 7(9), 715-725. https://doi.org/10.1016/S2213-8587(19)30084

Opoku, A. A., Abushama, M., & Konje, J. C. (2023). Obesity and menopause. Best Pract Res Clin Obstet Gynaecol, 88, 102348. https://doi.org/10.1016/j.bpobgyn.2023.102348

Park, J. H., Kwon, S., & Park, Y. M. (2023). Extracellular Vimentin Alters Energy Metabolism And Induces Adipocyte Hypertrophy. Diabetes Metab J. Advance online publication. https://doi.org/10.4093/dmj.2022.0332

Pahlavani, N., Nattagh-Eshtivani, E., Amanollahi, A., Ranjbar, G., Aghdaei, H. A., Navashenaq, J. G., Shabaninezhad, Z., Sharahi, N. R., Maleki, M., Malekahmadi, M., & Norouzy, A. (2022). Effects of microwave technology on the subcutaneous abdominal fat and anthropometric indices of overweight adults: A clinical trial. Journal of Cosmetic Dermatology, 21(4), 1482-1488. https://doi.org/10.1111/jocd.14245

Peycheva, D., Sullivan, A., Hardy, R., Bryson, A., Conti, G., & Ploubidis, G. (2022). Risk factors for natural menopause before the age of 45: evidence from two British population-based birth cohort studies. BMC Women’s Health, 22(1), 438. https://doi.org/10.1186/s12905-022-02021-4

Piłat, P., Szpila, G., Stojko, M., Nocoń, J., Smolarczyk, J., Żmudka, K., Moll, M., & Hawranek, M. (2023). Modern and Non-Invasive Methods of Fat Removal. Medicina (Kaunas), 59(8), 1378. https://doi.org/10.3390/medicina59081378

Ryan, A. S., Ortmeyer, H. K., & Sorkin, J. D. (2012). Exercise with calorie restriction improves insulin sensitivity and glycogen synthase activity in obese postmenopausal women with impaired glucose tolerance. American Journal of Physiology-Endocrinology and Metabolism, 302(1), E145-E152. https://doi.org/10.1152/ajpendo.00618.2010

Tettamanzi, M., Pili, N., Rodio, M., Serra, P. L., Trignano, C., Rubino, C., & Trignano, E. (2023). Use of Radiofrequency-Assisted Liposuction (BodyTite) for Upper Arms Lifting. Aesthetic Plastic Surgery, 47(6), 2495-2501. https://doi.org/10.1007/s00266-023-03452-6

Vale, A. L., Pereira, A. S., Morais, A., Noites, A., Mendonça, A. C., Martins Pinto, J., Vilarinho, R., & Carvalho, P. (2018). Effects of radiofrequency on adipose tissue: A systematic review with meta-analysis. Journal of Cosmetic Dermatology, 17(5), 703-711. https://doi.org/10.1111/jocd.12776

Varma, B., Ogunmoroti, O., Ndumele, C. E., Kazzi, B., Rodriquez, C. P., Osibogun, O., Allison, M. A., Bertoni, A. G., & Michos, E. D. (2023). Associations between endogenous sex hormone levels and adipokine levels in the Multi-Ethnic Study of Atherosclerosis. Frontiers in Cardiovascular Medicine, 9, 1062460. https://doi.org/10.3389/fcvm.2022.1062460

Wanitphakdeedecha, R., Yogya, Y., Yan, C., Phumariyapong, P., Nanchaipruek, Y., Thongjaroensirikul, P., Maneeprasopchoke, P., Techapichetvanich, T., Eimpunth, S., & Manuskiatti, W. (2022). Efficacy and Safety of Monopolar Radiofrequency for Treatment of Lower Facial Laxity in Asians. Dermatologic Therapy (Heidelb), 12(11), 2563-2573. https://doi.org/10.1007/s13555-022-00817-8

Weiss, R., Weiss, M., Beasley, K., Vrba, J., & Bernardy, J. (2013). Operator independent focused high frequency ISM band for fat reduction: porcine model. Lasers in Surgery and Medicine, 45(4), 235-239. https://doi.org/10.1002/lsm.22134